| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
|---|
| Ligand | BDBM50237998 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1662734 (CHEMBL4012415) |
|---|
| IC50 | 500±n/a nM |
|---|
| Citation |  Liddle, J; Beaufils, B; Binnie, M; Bouillot, A; Denis, AA; Hann, MM; Haslam, CP; Holmes, DS; Hutchinson, JP; Kranz, M; McBride, A; Mirguet, O; Mole, DJ; Mowat, CG; Pal, S; Rowland, P; Trottet, L; Uings, IJ; Walker, AL; Webster, SP The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg Med Chem Lett27:2023-2028 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kynurenine 3-monooxygenase |
|---|
| Name: | Kynurenine 3-monooxygenase |
|---|
| Synonyms: | 1.14.13.9 | KMO_PSEFL | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase | PfKMO | kmo | qbsG |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50713.22 |
|---|
| Organism: | Pseudomonas fluorescens |
|---|
| Description: | ChEMBL_117445 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MTATDNARQVTIIGAGLAGTLVARLLARNGWQVNLFERRPDPRIETGARGRSINLALAER
GAHALRLAGLEREVLAEAVMMRGRMVHVPGTPPNLQPYGRDDSEVIWSINRDRLNRILLD
GAEAAGASIHFNLGLDSVDFARQRLTLSNVSGERLEKRFHLLIGADGCNSAVRQAMASVV
DLGEHLETQPHGYKELQITPEASAQFNLEPNALHIWPHGDYMCIALPNLDRSFTVTLFLH
HQSPAAQPASPCFAQLVDGHAARRFFQRQFPDLSPMLDSLEQDFEHHPTGKLATLRLTTW
HVGGQAVLLGDAAHPMVPFHGQGMNCALEDAVALAEHLQSAADNASALAAFTAQRQPDAL
AIQAMALENYVEMSSKVASPTYLLERELGQIMAQRQPTRFIPRYSMVTFSRLPYAQAMAR
GQIQEQLLKFAVANHSDLTSINLDAVEHEVTRCLPPLSHLC
|
|
|
|---|
| BDBM50237998 |
|---|
| n/a |
|---|
| Name | BDBM50237998 |
|---|
| Synonyms: | CHEMBL1881960 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C7H3Cl2NO2 |
|---|
| Mol. Mass. | 204.01 |
|---|
| SMILES | Oc1nc2cc(Cl)c(Cl)cc2o1 |
|---|
| Structure | 
|
|---|
Search and Browse
