Reaction Details |
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Target | Cytochrome P450 11B2, mitochondrial |
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Ligand | BDBM50238115 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1662801 (CHEMBL4012482) |
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IC50 | >100±n/a nM |
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Citation | Meguro, M; Miyauchi, S; Kanao, Y; Naito, S; Suzuki, K; Inoue, S; Yamada, K; Homma, T; Chiba, K; Nara, F; Furuzono, S 4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures. Bioorg Med Chem Lett27:1902-1906 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B2, mitochondrial |
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Name: | Cytochrome P450 11B2, mitochondrial |
Synonyms: | Aldosterone synthase | C11B2_MOUSE | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B2, mitochondrial | Cytochrome P450C11 | Steroid 11-beta-hydroxylase |
Type: | PROTEIN |
Mol. Mass.: | 57397.51 |
Organism: | Mus musculus |
Description: | ChEMBL_109884 |
Residue: | 500 |
Sequence: | MALRVTADVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQG
QENLHLEMHQVFRELGPIFRHSVGKTQIVSVMLPEDAEKLHQVESMLPRRMHLEPWVAHR
ELRGLRRGVFLLNGPEWRLNRLRLNRNVLSPKAVQKFVPMVDMVARDFLETLKEKVLQNA
RGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLSPGSLKFIHALHSMFKSTSQLLFL
PKSLTRWTSTRVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAELISQGSLP
LDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQKALRQESLAAEASIAANPQKAMS
DLPLLRAALKETLRLYPVGGFLERILSSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRP
ERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMMLLLHHILKTFQVETLRQEDVQM
AYRFVLMPSSSPVLTFRPVS
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BDBM50238115 |
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n/a |
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Name | BDBM50238115 |
Synonyms: | CHEMBL4082403 |
Type | Small organic molecule |
Emp. Form. | C18H20F4N4O3S |
Mol. Mass. | 448.435 |
SMILES | CS(=O)(=O)N1CCC(CC1)C(O)(c1cncnc1Nc1ccc(F)cc1)C(F)(F)F |
Structure |
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