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TargetGlutaminase liver isoform, mitochondrial
LigandBDBM50238210
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1663489 (CHEMBL4013170)
IC50 1185±n/a nM
Citation Yeh, TKKuo, CCLee, YZKe, YYChu, KFHsu, HYChang, HYLiu, YWSong, JSYang, CWLin, LMSun, MWu, SHKuo, PCShih, CChen, CTTsou, LKLee, SJ Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors. J Med Chem60:5599-5612 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glutaminase liver isoform, mitochondrial
Name:Glutaminase liver isoform, mitochondrial
Synonyms:3.5.1.2 | GA | GLS | GLS2 | GLSL_HUMAN | Glutaminase liver isoform, mitochondrial | L-glutaminase | L-glutamine amidohydrolase
Type:PROTEIN
Mol. Mass.:66331.64
Organism:Homo sapiens
Description:ChEMBL_117753
Residue:602
Sequence:
MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD
HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ
ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA
AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA
EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES
MV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238210
n/a
NameBDBM50238210
Synonyms:CHEMBL4065595
TypeSmall organic molecule
Emp. Form.C29H22N4O4S2
Mol. Mass.554.639
SMILESCCc1cc(ccc1\C=C1/SC(=O)NC1=O)-c1ccc(cc1C#N)-n1c(C)cc(\C=C2/SC(=O)NC2=O)c1C
Structure
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