Reaction Details |
| Report a problem with these data |
Target | Macrophage metalloelastase |
---|
Ligand | BDBM50033809 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1663588 (CHEMBL4013269) |
---|
IC50 | 70±n/a nM |
---|
Citation | Durham, TB; Marimuthu, J; Toth, JL; Liu, C; Adams, L; Mudra, DR; Swearingen, C; Lin, C; Chambers, MG; Thirunavukkarasu, K; Wiley, MR A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose. J Med Chem60:5933-5939 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Macrophage metalloelastase |
---|
Name: | Macrophage metalloelastase |
Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
Type: | Enzyme |
Mol. Mass.: | 54012.99 |
Organism: | Homo sapiens (Human) |
Description: | P39900 |
Residue: | 470 |
Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
|
|
|
BDBM50033809 |
---|
n/a |
---|
Name | BDBM50033809 |
Synonyms: | CHEMBL3358151 |
Type | Small organic molecule |
Emp. Form. | C13H14ClN3O4 |
Mol. Mass. | 311.721 |
SMILES | C[C@]1(CNC(=O)COc2ccc(Cl)cc2)NC(=O)NC1=O |r| |
Structure |
|