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TargetComplement factor D
LigandBDBM170709
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1663607 (CHEMBL4013288)
IC50 300±n/a nM
Citation Lorthiois, EAnderson, KVulpetti, ARogel, OCumin, FOstermann, NSteinbacher, SMac Sweeney, ADelgado, OLiao, SMRandl, SRüdisser, SDussauge, SFettis, KKieffer, Lde Erkenez, AYang, LHartwieg, CArgikar, UALa Bonte, LRNewton, RKansara, VFlohr, SHommel, UJaffee, BMaibaum, J Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J Med Chem60:5717-5735 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Complement factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
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  Blast E-value cutoff:
BDBM170709
n/a
NameBDBM170709
Synonyms:US9085555, 137
TypeSmall organic molecule
Emp. Form.C23H22F3N5O4
Mol. Mass.489.4471
SMILESC[C@H]1C[C@H](N(C1)C(=O)Nc1cn(C(N)=O)c2ccccc12)C(=O)Nc1cccc(OC(F)(F)F)c1 |r|
Structure
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