Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetComplement factor D
LigandBDBM50238247
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1663607 (CHEMBL4013288)
IC50 15±n/a nM
Citation Lorthiois, EAnderson, KVulpetti, ARogel, OCumin, FOstermann, NSteinbacher, SMac Sweeney, ADelgado, OLiao, SMRandl, SRüdisser, SDussauge, SFettis, KKieffer, Lde Erkenez, AYang, LHartwieg, CArgikar, UALa Bonte, LRNewton, RKansara, VFlohr, SHommel, UJaffee, BMaibaum, J Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J Med Chem60:5717-5735 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Complement factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238247
n/a
NameBDBM50238247
Synonyms:CHEMBL4081888
TypeSmall organic molecule
Emp. Form.C22H20BrN5O3
Mol. Mass.482.33
SMILES[H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)Nc1cccc(Br)n1)C(=O)Cn1nc(C(C)=O)c2ccccc12 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: