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TargetProtein mono-ADP-ribosyltransferase PARP11
LigandBDBM50238419
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1663206 (CHEMBL4012887)
IC50<5012±n/a nM
Citation Thomson, DWWagner, AJBantscheff, MBenson, REDittus, LDuempelfeld, BDrewes, GKrause, JMoore, JTMueller, KPoeckel, DRau, CSalzer, EShewchuk, LHopf, CEmery, JGMuelbaier, M Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines. J Med Chem60:5455-5471 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein mono-ADP-ribosyltransferase PARP11
Name:Protein mono-ADP-ribosyltransferase PARP11
Synonyms:2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 11 | ARTD11 | C12orf6 | PAR11_HUMAN | PARP-11 | PARP11 | Poly [ADP-ribose] polymerase 11
Type:PROTEIN
Mol. Mass.:39601.40
Organism:Homo sapiens
Description:ChEMBL_107591
Residue:338
Sequence:
MWEANPEMFHKAEELFSKTTNNEVDDMDTSDTQWGWFYLAECGKWHMFQPDTNSQCSVSS
EDIEKSFKTNPCGSISFTTSKFSYKIDFAEMKQMNLTTGKQRLIKRAPFSISAFSYICEN
EAIPMPPHWENVNTQVPYQLIPLHNQTHEYNEVANLFGKTMDRNRIKRIQRIQNLDLWEF
FCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRINGIHGAVFGKGTYFARD
AAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSK
DGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH
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  Blast E-value cutoff:
BDBM50238419
n/a
NameBDBM50238419
Synonyms:CHEMBL4060134
TypeSmall organic molecule
Emp. Form.C24H22N10O2
Mol. Mass.482.4973
SMILESCn1cnc(c1)C(=O)N1CCN(CC1)C(=O)c1ccc(Nc2nc3ccccc3n3nnnc23)cc1
Structure
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