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TargetBaculoviral IAP repeat-containing protein 2/Estrogen receptor
LigandBDBM50238742
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1664056
Ki 0.370000±n/a nM
Citation Min JGuillen VSSharma AZhao YZiegler YGong PMayne CGSrinivasan SKim SHCarlson KENettles KWKatzenellenbogen BSKatzenellenbogen JA Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells. J Med Chem 60:6321-6336 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Baculoviral IAP repeat-containing protein 2/Estrogen receptor
Name:Baculoviral IAP repeat-containing protein 2/Estrogen receptor
Synonyms:ER | ER-alpha | ESR | ESR1 | Estradiol receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:Protein
Mol. Mass.:66230.44
Organism:Homo sapiens (Human)
Description:P03372
Residue:595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238742
n/a
NameBDBM50238742
Synonyms:CHEMBL4062045
TypeSmall organic molecule
Emp. Form.C29H34N2O2
Mol. Mass.442.5925
SMILESNCCCNC(=O)\C=C\c1ccc(cc1)C(=C1C2CC3CC(C2)CC1C3)c1ccc(O)cc1 |TLB:15:16:18:22.20.21,THB:20:19:16:22.21.23,20:21:18.19.25:16,23:21:18:25.24.16,23:24:18:22.20.21,(26.16,-25.06,;27.49,-25.83,;28.82,-25.07,;30.15,-25.84,;31.49,-25.08,;32.82,-25.85,;32.82,-27.39,;34.16,-25.09,;35.5,-25.86,;36.83,-25.09,;36.83,-23.54,;38.16,-22.77,;39.5,-23.54,;39.5,-25.09,;38.16,-25.86,;40.83,-22.76,;42.16,-23.53,;42.17,-25.02,;40.98,-26.29,;42.47,-25.87,;43.88,-26.43,;44.89,-25.16,;43.49,-25.5,;44.91,-23.63,;43.5,-23.06,;42.46,-24.28,;40.82,-21.22,;42.16,-20.46,;42.15,-18.92,;40.81,-18.15,;40.81,-16.61,;39.48,-18.93,;39.49,-20.47,)|
Structure
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