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TargetBaculoviral IAP repeat-containing protein 2/Estrogen receptor
LigandBDBM50238724
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1664056
Ki 0.180000±n/a nM
Citation Min JGuillen VSSharma AZhao YZiegler YGong PMayne CGSrinivasan SKim SHCarlson KENettles KWKatzenellenbogen BSKatzenellenbogen JA Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells. J Med Chem 60:6321-6336 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Baculoviral IAP repeat-containing protein 2/Estrogen receptor
Name:Baculoviral IAP repeat-containing protein 2/Estrogen receptor
Synonyms:ER | ER-alpha | ESR | ESR1 | Estradiol receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:Protein
Mol. Mass.:66230.44
Organism:Homo sapiens (Human)
Description:P03372
Residue:595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238724
n/a
NameBDBM50238724
Synonyms:CHEMBL4060067
TypeSmall organic molecule
Emp. Form.C28H31NO3
Mol. Mass.429.5506
SMILESOCCNC(=O)\C=C\c1ccc(cc1)C(=C1C2CC3CC(C2)CC1C3)c1ccc(O)cc1 |TLB:14:15:17:21.19.20,THB:19:18:15:21.20.22,19:20:17.18.24:15,22:20:17:24.23.15,22:23:17:21.19.20,(52.34,-39.29,;53.68,-38.52,;55.01,-39.3,;56.35,-38.53,;57.68,-39.31,;57.67,-40.85,;59.02,-38.54,;60.35,-39.31,;61.69,-38.54,;61.69,-37,;63.02,-36.23,;64.35,-36.99,;64.36,-38.54,;63.02,-39.31,;65.69,-36.22,;67.02,-36.98,;67.03,-38.47,;65.83,-39.74,;67.33,-39.33,;68.74,-39.89,;69.75,-38.61,;68.35,-38.96,;69.76,-37.08,;68.36,-36.51,;67.32,-37.74,;65.68,-34.68,;67.01,-33.91,;67.01,-32.37,;65.67,-31.61,;65.66,-30.07,;64.34,-32.39,;64.35,-33.93,)|
Structure
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