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TargetBaculoviral IAP repeat-containing protein 2/Estrogen receptor
LigandBDBM50238737
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1664056
Ki 0.400000±n/a nM
Citation Min JGuillen VSSharma AZhao YZiegler YGong PMayne CGSrinivasan SKim SHCarlson KENettles KWKatzenellenbogen BSKatzenellenbogen JA Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells. J Med Chem 60:6321-6336 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Baculoviral IAP repeat-containing protein 2/Estrogen receptor
Name:Baculoviral IAP repeat-containing protein 2/Estrogen receptor
Synonyms:ER | ER-alpha | ESR | ESR1 | Estradiol receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:Protein
Mol. Mass.:66230.44
Organism:Homo sapiens (Human)
Description:P03372
Residue:595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238737
n/a
NameBDBM50238737
Synonyms:CHEMBL4083658
TypeSmall organic molecule
Emp. Form.C26H26O3
Mol. Mass.386.4828
SMILESOC(=O)\C=C\c1ccc(cc1)C(=C1C2CC3CC(C2)CC1C3)c1ccc(O)cc1 |TLB:11:12:14:18.16.17,THB:16:15:12:18.17.19,16:17:14.15.21:12,19:17:14:21.20.12,19:20:14:18.16.17,(2.75,-38.67,;4.08,-39.44,;4.08,-40.98,;5.42,-38.67,;6.75,-39.45,;8.08,-38.68,;8.09,-37.13,;9.42,-36.36,;10.75,-37.13,;10.76,-38.68,;9.42,-39.45,;12.08,-36.35,;13.42,-37.11,;13.43,-38.61,;12.23,-39.88,;13.72,-39.46,;15.14,-40.02,;16.14,-38.74,;14.75,-39.09,;16.16,-37.22,;14.76,-36.64,;13.72,-37.87,;12.08,-34.81,;13.41,-34.04,;13.4,-32.51,;12.07,-31.74,;12.06,-30.2,;10.73,-32.52,;10.74,-34.06,)|
Structure
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