Reaction Details |
| Report a problem with these data |
Target | Carbonic anhydrase 9 |
---|
Ligand | BDBM33412 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1664111 (CHEMBL4013792) |
---|
Ki | 480±n/a nM |
---|
Citation | Falsini, M; Squarcialupi, L; Catarzi, D; Varano, F; Betti, M; Di Cesare Mannelli, L; Tenci, B; Ghelardini, C; Tanc, M; Angeli, A; Supuran, CT; Colotta, V 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII. J Med Chem60:6428-6439 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Carbonic anhydrase 9 |
---|
Name: | Carbonic anhydrase 9 |
Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
Type: | Enzyme |
Mol. Mass.: | 49669.03 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 459 |
Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
|
|
|
BDBM33412 |
---|
n/a |
---|
Name | BDBM33412 |
Synonyms: | CHEMBL183852 | N-hydroxy quinazolinedione, 4 | US11253521, No. 12 |
Type | Small organic molecule |
Emp. Form. | C8H6N2O3 |
Mol. Mass. | 178.1448 |
SMILES | On1c(=O)[nH]c2ccccc2c1=O |
Structure |
|