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TargetDual specificity protein kinase CLK4
LigandBDBM50238867
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1664434 (CHEMBL4014115)
IC50 8.0±n/a nM
Citation Sun, QZSun, QZLin, GFLin, GFLi, LLLi, LLJin, XTJin, XTHuang, LYHuang, LYZhang, GZhang, GYang, WYang, WChen, KChen, KXiang, RXiang, RChen, CChen, CWei, YQWei, YQLu, GWLu, GWYang, SYYang, SY Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers. J Med Chem60:6337-6352 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity protein kinase CLK4
Name:Dual specificity protein kinase CLK4
Synonyms:CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4
Type:Serine/threonine-protein kinase
Mol. Mass.:57522.53
Organism:Homo sapiens (Human)
Description:gi_10190706
Residue:481
Sequence:
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
K
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238867
n/a
NameBDBM50238867
Synonyms:CHEMBL4083249
TypeSmall organic molecule
Emp. Form.C24H16FN5O
Mol. Mass.409.4151
SMILESC[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Structure
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