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TargetN-formyl peptide receptor 2
LigandBDBM50238904
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1664517 (CHEMBL4014198)
IC50 94±n/a nM
Citation Skovbakke, SL; Skovbakke, SL; Skovbakke, SL; Holdfeldt, A; Holdfeldt, A; Holdfeldt, A; Nielsen, C; Nielsen, C; Nielsen, C; Hansen, AM; Hansen, AM; Hansen, AM; Perez-Gassol, I; Perez-Gassol, I; Perez-Gassol, I; Dahlgren, C; Dahlgren, C; Dahlgren, C; Forsman, H; Forsman, H; Forsman, H; Franzyk, H; Franzyk, H; Franzyk, H Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists. J Med Chem60:6991-6997 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
N-formyl peptide receptor 2
Name:N-formyl peptide receptor 2
Synonyms:ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:38968.35
Organism:Homo sapiens (Human)
Description:P25090
Residue:351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVT
TICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIA
LDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNF
ASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPL
RVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPM
LYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238904
n/a
NameBDBM50238904
Synonyms:CHEMBL4082656
TypeSmall organic molecule
Emp. Form.C130H164F18N21O14
Mol. Mass.2586.7962
SMILESCCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(cc3)C(F)(F)F)Cc3ccc(cc3)C(F)(F)F)Cc3ccc(cc3)C(F)(F)F)Cc3ccc(cc3)C(F)(F)F)Cc3ccc(cc3)C(F)(F)F)Cc3ccc(cc3)C(F)(F)F)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:89.90,47.48,61.62,33.34,wD:75.76,19.20,(20.86,-17.1,;19.54,-16.33,;18.21,-17.1,;18.21,-18.64,;19.54,-19.41,;16.86,-16.33,;16.86,-14.81,;15.53,-14.04,;14.2,-14.81,;12.87,-14.05,;12.86,-11.99,;11.52,-11.23,;11.52,-9.69,;12.85,-8.91,;14.17,-9.68,;14.17,-11.21,;15.5,-11.99,;15.5,-13.54,;16.86,-11.21,;18.21,-11.99,;18.21,-13.54,;19.54,-14.31,;19.54,-15.84,;20.87,-16.61,;22.2,-15.84,;19.55,-11.21,;19.55,-9.65,;20.89,-11.99,;20.9,-13.52,;22.23,-14.29,;23.56,-13.51,;23.56,-11.98,;24.9,-14.28,;26.22,-13.51,;26.22,-11.97,;27.56,-11.19,;27.55,-9.65,;28.88,-8.88,;28.87,-7.35,;27.56,-14.27,;27.57,-15.81,;28.89,-13.5,;30.22,-14.27,;30.22,-15.81,;31.57,-16.57,;32.89,-15.79,;31.56,-18.1,;32.9,-18.87,;34.23,-18.1,;35.55,-18.86,;36.89,-18.09,;38.23,-18.86,;39.55,-18.09,;32.9,-20.41,;31.58,-21.18,;34.23,-21.17,;34.24,-22.71,;32.91,-23.49,;32.91,-25.02,;34.24,-25.78,;31.59,-25.79,;31.59,-27.34,;32.92,-28.1,;32.93,-29.64,;34.26,-30.41,;35.59,-29.64,;36.94,-30.41,;30.25,-28.11,;28.92,-27.34,;30.25,-29.65,;31.6,-30.42,;31.6,-31.96,;30.26,-32.73,;28.93,-31.97,;30.27,-34.28,;28.93,-35.05,;27.6,-34.28,;26.26,-35.06,;24.93,-34.29,;23.59,-35.06,;22.26,-34.3,;28.94,-36.59,;30.27,-37.36,;27.61,-37.37,;27.61,-38.91,;26.27,-39.68,;26.28,-41.22,;27.62,-41.99,;24.94,-42,;24.95,-43.54,;26.28,-44.31,;26.29,-45.85,;27.63,-46.62,;28.96,-45.84,;30.3,-46.61,;23.62,-44.31,;22.28,-43.55,;23.62,-45.86,;24.96,-46.62,;24.96,-48.16,;26.29,-48.93,;26.3,-50.47,;27.63,-48.16,;22.29,-46.63,;20.95,-45.86,;19.62,-46.64,;18.29,-45.88,;18.28,-44.33,;19.61,-43.55,;20.95,-44.32,;16.94,-43.56,;16.94,-42.02,;15.61,-44.34,;15.6,-42.79,;26.26,-36.6,;24.93,-37.37,;23.6,-36.6,;22.27,-37.37,;22.27,-38.92,;23.62,-39.68,;24.94,-38.91,;20.94,-39.69,;19.6,-38.93,;20.94,-41.24,;19.59,-40.46,;28.92,-30.43,;27.59,-29.66,;26.26,-30.43,;24.93,-29.67,;24.92,-28.12,;26.25,-27.35,;27.59,-28.12,;23.58,-27.36,;23.57,-25.81,;22.25,-28.13,;22.23,-26.58,;35.56,-20.41,;36.9,-21.17,;36.9,-22.7,;38.23,-23.47,;39.56,-22.7,;39.55,-21.15,;38.22,-20.39,;40.9,-23.46,;40.91,-25,;42.23,-22.68,;42.23,-24.23,;28.88,-11.96,;30.21,-11.18,;30.2,-9.65,;31.53,-8.88,;32.87,-9.64,;32.88,-11.19,;31.55,-11.96,;34.2,-8.86,;35.54,-9.63,;34.2,-7.32,;35.53,-8.08,;22.23,-11.22,;22.22,-9.66,;20.89,-8.92,;20.88,-7.38,;22.22,-6.59,;23.55,-7.37,;23.56,-8.9,;22.21,-5.05,;23.55,-4.28,;20.87,-4.28,;22.2,-3.51,;11.54,-14.84,;10.21,-14.07,;8.89,-14.85,;8.91,-16.39,;10.22,-17.15,;11.54,-16.37,;12.89,-17.13,;14.21,-16.35,;15.55,-17.12,;7.56,-17.16,;7.56,-18.69,;6.22,-19.46,;6.22,-16.39,;4.88,-17.16,)|
Structure
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