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TargetN-formyl peptide receptor 2
LigandBDBM50238909
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1664517 (CHEMBL4014198)
IC50 24±n/a nM
Citation Skovbakke, SL; Skovbakke, SL; Skovbakke, SL; Holdfeldt, A; Holdfeldt, A; Holdfeldt, A; Nielsen, C; Nielsen, C; Nielsen, C; Hansen, AM; Hansen, AM; Hansen, AM; Perez-Gassol, I; Perez-Gassol, I; Perez-Gassol, I; Dahlgren, C; Dahlgren, C; Dahlgren, C; Forsman, H; Forsman, H; Forsman, H; Franzyk, H; Franzyk, H; Franzyk, H Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists. J Med Chem60:6991-6997 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
N-formyl peptide receptor 2
Name:N-formyl peptide receptor 2
Synonyms:ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:38968.35
Organism:Homo sapiens (Human)
Description:P25090
Residue:351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVT
TICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIA
LDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNF
ASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPL
RVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPM
LYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238909
n/a
NameBDBM50238909
Synonyms:CHEMBL4062611
TypeSmall organic molecule
Emp. Form.C130H182N21O14
Mol. Mass.2262.9678
SMILESCCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:89.90,47.48,61.62,33.34,wD:75.76,19.20,(18.68,-25.46,;17.36,-24.7,;16.03,-25.47,;16.03,-27.01,;17.36,-27.78,;14.68,-24.7,;14.68,-23.17,;13.35,-22.41,;12.02,-23.18,;10.69,-22.41,;10.68,-20.36,;9.34,-19.6,;9.34,-18.06,;10.67,-17.27,;11.99,-18.05,;11.99,-19.58,;13.32,-20.36,;13.32,-21.91,;14.68,-19.58,;16.03,-20.36,;16.03,-21.91,;17.35,-22.68,;17.35,-24.21,;18.69,-24.98,;20.02,-24.21,;17.37,-19.58,;17.37,-18.01,;18.71,-20.36,;18.72,-21.89,;20.05,-22.65,;21.38,-21.88,;21.38,-20.34,;22.71,-22.65,;24.04,-21.88,;24.04,-20.33,;25.37,-19.55,;25.37,-18.01,;26.7,-17.24,;26.69,-15.71,;25.38,-22.64,;25.38,-24.17,;26.71,-21.87,;28.04,-22.64,;28.04,-24.17,;29.38,-24.93,;30.71,-24.16,;29.38,-26.47,;30.72,-27.24,;32.05,-26.47,;33.37,-27.23,;34.71,-26.46,;36.05,-27.23,;37.37,-26.45,;30.72,-28.77,;29.39,-29.55,;32.05,-29.54,;32.06,-31.08,;30.73,-31.85,;30.73,-33.39,;32.06,-34.15,;29.4,-34.16,;29.41,-35.7,;30.74,-36.47,;30.75,-38.01,;32.08,-38.78,;33.41,-38.01,;34.76,-38.77,;28.07,-36.48,;26.73,-35.71,;28.07,-38.02,;29.42,-38.79,;29.42,-40.33,;28.08,-41.1,;26.75,-40.33,;28.08,-42.64,;26.75,-43.42,;25.42,-42.65,;24.08,-43.42,;22.74,-42.66,;21.41,-43.43,;20.08,-42.66,;26.76,-44.96,;28.09,-45.73,;25.43,-45.73,;25.43,-47.27,;24.09,-48.05,;24.09,-49.59,;25.44,-50.36,;22.76,-50.36,;22.77,-51.91,;24.1,-52.67,;24.1,-54.22,;25.45,-54.98,;26.78,-54.21,;28.11,-54.98,;21.44,-52.68,;20.1,-51.91,;21.44,-54.22,;22.77,-54.99,;22.78,-56.53,;24.11,-57.3,;24.12,-58.84,;25.45,-56.52,;20.11,-55,;18.76,-54.23,;18.77,-52.69,;17.43,-51.92,;16.1,-52.69,;14.76,-51.93,;16.11,-54.24,;17.44,-55,;24.08,-44.97,;22.75,-45.74,;21.42,-44.97,;20.09,-45.74,;20.09,-47.28,;18.76,-48.06,;21.43,-48.05,;22.76,-47.27,;26.74,-38.79,;25.41,-38.02,;25.41,-36.48,;24.07,-35.71,;22.74,-36.49,;21.4,-35.72,;22.75,-38.04,;24.08,-38.8,;33.38,-28.77,;34.71,-29.53,;34.72,-31.07,;36.05,-31.84,;37.38,-31.07,;38.72,-31.83,;37.37,-29.52,;36.04,-28.76,;26.7,-20.33,;28.03,-19.55,;28.02,-18.01,;29.35,-17.24,;30.69,-18.01,;32.02,-17.23,;30.69,-19.55,;29.37,-20.33,;20.05,-19.58,;20.04,-18.03,;18.71,-17.29,;18.7,-15.75,;20.04,-14.96,;20.03,-13.42,;21.37,-15.74,;21.38,-17.27,;9.36,-23.2,;8.03,-22.44,;6.71,-23.22,;6.73,-24.76,;8.04,-25.51,;9.36,-24.74,;10.71,-25.5,;12.03,-24.72,;13.37,-25.48,;5.38,-25.52,;5.38,-27.06,;4.04,-27.83,;4.04,-24.76,;2.7,-25.52,)|
Structure
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