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TargetHexokinase-4
LigandBDBM50239046
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1664962 (CHEMBL4014758)
EC50 3.9±n/a nM
Citation Xu, JLin, SMyers, RWAddona, GBerger, JPCampbell, BChen, HSChen, ZEiermann, GJElowe, NHFarrer, BTFeng, WFu, QKats-Kagan, RKavana, MMalkani, SMcMasters, DRMitra, KPachanski, MJTong, XTrujillo, MEXu, LZhang, BZhang, FZhang, RParmee, ER Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus. Bioorg Med Chem Lett27:2069-2073 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hexokinase-4
Name:Hexokinase-4
Synonyms:Gck | HXK4_RAT | Hexokinase type IV
Type:PROTEIN
Mol. Mass.:52101.81
Organism:Rattus norvegicus
Description:ChEMBL_1279785
Residue:465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGE
LVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPS
VTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
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  Blast E-value cutoff:
BDBM50239046
n/a
NameBDBM50239046
Synonyms:CHEMBL4068048
TypeSmall organic molecule
Emp. Form.C27H28N4O5S
Mol. Mass.520.6
SMILESCN1C(CCC1=O)c1cc2[nH]c(cc2cc1Oc1ccc(nc1)S(C)(=O)=O)-c1ccc(cn1)C(C)(C)O
Structure
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