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TargetCasein kinase I Epsilon
LigandBDBM274535
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 0.096±n/a nM
Commentsextracted
Citation Velaparthi UDarne CPDodd DSSampognaro AJWittman MDKumaravel SMullick DLiu PRachamreddy CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent  US9556179 Publication Date 1/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Casein kinase I Epsilon
Name:Casein kinase I delta/epsilon
Synonyms:CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon)
Type:Protein
Mol. Mass.:47340.25
Organism:Homo sapiens (Human)
Description:P49674
Residue:416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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  Blast E-value cutoff:
BDBM274535
n/a
NameBDBM274535
Synonyms:N-(6-(4-(4-fluorophenyl)- 1-(1-(2-hydroxyethyl) piperidin-4-yl)-1H-imidazol- 5-yl)imidazo[1,2-b]pyridazin- 2-yl)-4-methyl-2-(pyridin-4-yl) thiazole-5-carboxamide | US9556179, Compound 105
TypeSmall organic molecule
Emp. Form.C32H30FN9O2S
Mol. Mass.623.703
SMILESCc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(ncn1C1CCN(CCO)CC1)-c1ccc(F)cc1)-c1ccncc1
Structure
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