Reaction Details |
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Target | Casein kinase I isoform epsilon |
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Ligand | BDBM274535 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinase Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 0.096±n/a nM |
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Comments | extracted |
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Citation | Velaparthi, U; Darne, CP; Dodd, DS; Sampognaro, AJ; Wittman, MD; Kumaravel, S; Mullick, D; Liu, P; Rachamreddy, CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent US9556179 Publication Date 1/31/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Casein kinase I isoform epsilon |
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Name: | Casein kinase I isoform epsilon |
Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
Type: | Protein |
Mol. Mass.: | 47340.25 |
Organism: | Homo sapiens (Human) |
Description: | P49674 |
Residue: | 416 |
Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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BDBM274535 |
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n/a |
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Name | BDBM274535 |
Synonyms: | N-(6-(4-(4-fluorophenyl)- 1-(1-(2-hydroxyethyl) piperidin-4-yl)-1H-imidazol- 5-yl)imidazo[1,2-b]pyridazin- 2-yl)-4-methyl-2-(pyridin-4-yl) thiazole-5-carboxamide | US9556179, Compound 105 |
Type | Small organic molecule |
Emp. Form. | C32H30FN9O2S |
Mol. Mass. | 623.703 |
SMILES | Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(ncn1C1CCN(CCO)CC1)-c1ccc(F)cc1)-c1ccncc1 |
Structure |
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