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TargetCasein kinase I Epsilon
LigandBDBM274547
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 0.182±n/a nM
Commentsextracted
Citation Velaparthi UDarne CPDodd DSSampognaro AJWittman MDKumaravel SMullick DLiu PRachamreddy CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent  US9556179 Publication Date 1/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Casein kinase I Epsilon
Name:Casein kinase I delta/epsilon
Synonyms:CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon)
Type:Protein
Mol. Mass.:47340.25
Organism:Homo sapiens (Human)
Description:P49674
Residue:416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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  Blast E-value cutoff:
BDBM274547
n/a
NameBDBM274547
Synonyms:(S)—N-(6-(4-(4-fluorophenyl)-1-(1-(3,3,3-trifluoro-2-hydroxypropyl)piperidin-4-yl)-1H-imidazol-5-yl)imidazo[1,2-b]pyridazin-2-yl)thiazole-5-carboxamide | US9556179, Compound 118
TypeSmall organic molecule
Emp. Form.C27H24F4N8O2S
Mol. Mass.600.59
SMILESO[C@@H](CN1CCC(CC1)n1cnc(c1-c1ccc2nc(NC(=O)c3cncs3)cn2n1)-c1ccc(F)cc1)C(F)(F)F |r|
Structure
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