| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
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| Ligand | BDBM274690 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.719±n/a nM |
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| Comments | extracted |
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| Citation |  Velaparthi, U; Darne, CP; Dodd, DS; Sampognaro, AJ; Wittman, MD; Kumaravel, S; Mullick, D; Liu, P; Rachamreddy, CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent US9556179 Publication Date 1/31/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform epsilon |
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| Name: | Casein kinase I isoform epsilon |
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| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47340.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49674 |
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| Residue: | 416 |
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| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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| BDBM274690 |
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| n/a |
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| Name | BDBM274690 |
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| Synonyms: | 2-fluoro-N-(6-(4-(4-fluorophenyl)- 1-(2-(1H-pyrazol-4-yl)ethyl-1H- imidazol-5-yl)imidazo[1,2-b] pyridazin-2-yl)isonicotinamide | US9556179, Compound 265 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H19F2N9O |
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| Mol. Mass. | 511.4856 |
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| SMILES | Fc1ccc(cc1)-c1ncn(CCc2cn[nH]c2)c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1 |
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| Structure | 
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