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TargetCasein kinase I Epsilon
LigandBDBM274718
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 1.28±n/a nM
Commentsextracted
Citation Velaparthi UDarne CPDodd DSSampognaro AJWittman MDKumaravel SMullick DLiu PRachamreddy CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent  US9556179 Publication Date 1/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Casein kinase I Epsilon
Name:Casein kinase I delta/epsilon
Synonyms:CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon)
Type:Protein
Mol. Mass.:47340.25
Organism:Homo sapiens (Human)
Description:P49674
Residue:416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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  Blast E-value cutoff:
BDBM274718
n/a
NameBDBM274718
Synonyms:N-(6-(4-(4-chlorophenyl)-1-(2- fluoroethyl)-2-methyl-1H-imidazol- 5-yl)imidazo[1,2-b]pyridazin-2-yl)- 2-fluoroisonicotinamide | US9556179, Compound 293
TypeSmall organic molecule
Emp. Form.C24H18ClF2N7O
Mol. Mass.493.896
SMILESCc1nc(c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)n1CCF)-c1ccc(Cl)cc1
Structure
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