Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCasein kinase I isoform epsilon
LigandBDBM274724
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 0.760±n/a nM
Commentsextracted
Citation Velaparthi, UDarne, CPDodd, DSSampognaro, AJWittman, MDKumaravel, SMullick, DLiu, PRachamreddy, CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent US9556179 Publication Date 1/31/2017
More Info.:Get all data from this article,  Assay Method
 
Casein kinase I isoform epsilon
Name:Casein kinase I isoform epsilon
Synonyms:Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:Protein
Mol. Mass.:47340.25
Organism:Homo sapiens (Human)
Description:P49674
Residue:416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM274724
n/a
NameBDBM274724
Synonyms:2-fluoro-N-(6-(4-(4-fluoro-3- methylphenyl)-1-(2-fluoroethyl)- 2-methyl-1H-imidazol-5-yl) imidazo[1,2-b]pyridazin-2-yl) isonicotinamide | US9556179, Compound 299
TypeSmall organic molecule
Emp. Form.C25H20F3N7O
Mol. Mass.491.4678
SMILESCc1nc(c(-c2ccc3nc(NC(=O)c4ccnc(F)c4)cn3n2)n1CCF)-c1ccc(F)c(C)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: