| Reaction Details |
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 | Report a problem with these data |
| Target | D(4) dopamine receptor |
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| Ligand | BDBM50051563 |
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| Substrate/Competitor | n/a |
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| Ki | 10.1±n/a nM |
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| Comments | PDSP_1932 |
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| Citation |  Merchant, KM; Gill, GS; Harris, DW; Huff, RM; Eaton, MJ; Lookingland, K; Lutzke, BS; Mccall, RB; Piercey, MF; Schreur, PJ; Sethy, VH; Smith, MW; Svensson, KA; Tang, AH; Vonvoigtlander, PF; Tenbrink, RE Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist. J Pharmacol Exp Ther279:1392-403 (1996) [PubMed] |
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| More Info.: | Get all data from this article |
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| D(4) dopamine receptor |
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| Name: | D(4) dopamine receptor |
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| Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 48373.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21917 |
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| Residue: | 419 |
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| Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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| BDBM50051563 |
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| n/a |
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| Name | BDBM50051563 |
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| Synonyms: | 4-[4-((R)-2-Isochroman-1-yl-ethyl)-piperazin-1-yl]-benzenesulfonamide | CHEMBL81649 | U-101387 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27N3O3S |
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| Mol. Mass. | 401.522 |
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| SMILES | NS(=O)(=O)c1ccc(cc1)N1CCN(CC[C@H]2OCCc3ccccc23)CC1 |
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| Structure | 
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