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TargetHTR3A
LigandBDBM85079
Substrate/Competitorn/a
Ki 1100±n/a nM
CommentsPDSP_2284
Citation Mos JVan Hest AVan Drimmelen MHerremans AHOlivier B The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. Eur J Pharmacol 325:145-53 (1997) [PubMed]  Article
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HTR3A
Name:HTR3A
Synonyms:5-HT3
Type:Enzyme Catalytic Domain
Mol. Mass.:46633.35
Organism:pigeon
Description:5-HT3 HTR3A pigeon::A0A218UVI3
Residue:407
Sequence:
MIGILFPAGAAPKYLCTYYDIVDYLNISSHDKLHTYILPKKDLQEPVEVTMDFFLVAILS
VVEKLQTVSFYFVLNLEWQNPFATWNPRDFCNISEIVLPMDTYWSPPIFFLERVNGQNPE
LNYVVLMHNGSFNSTRPYQVTLTCSLIILKFPFDTQMCNLSVASFLYPVTDFVMKTRRTP
AEIMEDSRSFILTDGEWKFTNLSIVEFTAMMDDKGFSVVTYVISMERRPTLYVLNLILPT
CALYLLDMAVLFGPSSLEEKINFQIAIILGSSMLAVILNNSLPTSSNKPPIIVVFFLGTF
LLMIMAVLDTFFLLYQQRKSLRLDKVLRSFQQDPQELPKRPMGTLAKGGPQLLPPPKKAQ
GQGQLTKRLWQLQELDPFLPVLEKVLLFSHLFLSLIFFTVVSIKWSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM85079
n/a
NameBDBM85079
Synonyms:2-[4-[4-[(7-Chloro-2,3-dihydro-1,4-benzodioxin)-5-yl]-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide | CHEMBL79261 | DU-125530 | DU125530
TypeSmall organic molecule
Emp. Form.C23H26ClN3O5S
Mol. Mass.491.988
SMILESClc1cc2OCCOc2c(c1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
Structure
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