Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | 5-hydroxytryptamine receptor 2B | ||
Ligand | BDBM30704 | ||
Substrate/Competitor | n/a | ||
Ki | 0.74±n/a nM | ||
Comments | PDSP_1209 | ||
Citation | Bonhaus, DW; Weinhardt, KK; Taylor, M; DeSouza, A; McNeeley, PM; Szczepanski, K; Fontana, DJ; Trinh, J; Rocha, CL; Dawson, MW; Flippin, LA; Eglen, RM RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. Neuropharmacology36:621-9 (1997) [PubMed] Article | ||
More Info.: | Get all data from this article | ||
5-hydroxytryptamine receptor 2B | |||
Name: | 5-hydroxytryptamine receptor 2B | ||
Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 54312.47 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. | ||
Residue: | 481 | ||
Sequence: |
| ||
BDBM30704 | |||
n/a | |||
Name | BDBM30704 | ||
Synonyms: | (phenylmethyl) N-[[(6aR,9S,10aR)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-yl]methyl]carbamate | CHEMBL19215 | METERGOLINE | MLS000069437 | N-[[(6aR,9S,10aR)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-yl]methyl]carbamic acid (phenylmethyl) ester | N-[[(6aR,9S,10aR)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-yl]methyl]carbamic acid benzyl ester | SMR000059050 | benzyl N-[[(6aR,9S,10aR)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-yl]methyl]carbamate | cid_28693 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H29N3O2 | ||
Mol. Mass. | 403.5167 | ||
SMILES | CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@H]2[C@H]1Cc1cn(C)c3cccc2c13 | ||
Structure |