| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2A adrenergic receptor |
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| Ligand | BDBM85098 |
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| Substrate/Competitor | n/a |
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| Ki | 316.22±n/a nM |
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| Comments | PDSP_1626 |
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| Citation |  Bonhaus, DW; Weinhardt, KK; Taylor, M; DeSouza, A; McNeeley, PM; Szczepanski, K; Fontana, DJ; Trinh, J; Rocha, CL; Dawson, MW; Flippin, LA; Eglen, RM RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. Neuropharmacology36:621-9 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Alpha-2A adrenergic receptor |
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| Name: | Alpha-2A adrenergic receptor |
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| Synonyms: | ADRA2A | Alpha 2A adrenoceptor | adrenergic Alpha2A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49324.71 |
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| Organism: | RABBIT |
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| Description: | Q5ZQK3 |
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| Residue: | 451 |
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| Sequence: | MGSLQPDAGNGSWNGSEAPGGGARASPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGQAWCEIYLALDMLFCTSS
IAHLCAISLDRHWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIERKGGGGG
GGRQRCEINDHKWYVIASCTGSFFVPCLIMILVYVRIYQIAKRRTRVPPSRRVRTPPPPP
PPPPPPPRQPGPPSAGLMAWAPERGAGSASAETEPLPTQLNGAAGEPAAAGPRETDALDL
EESSSSEHAERPPGPASRGPRQGPSEPGEARGQHPSARARDRGARGVGGRARGDTPEAPR
RLWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPPTLFKFFFWFGYCNS
SLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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| BDBM85098 |
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| n/a |
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| Name | BDBM85098 |
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| Synonyms: | N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)benzenesulfonamide | RS-102221 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31F3N4O7S |
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| Mol. Mass. | 612.618 |
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| SMILES | [#6]-[#8]-c1cc(-[#8]-[#6])c(cc1-[#7][S;v6](=O)(=O)c1ccc(cc1)C(F)(F)F)-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]C2([#6]-[#6]-1)[#7]-[#6](=O)-[#7]-[#6]2=O |
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| Structure | 
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