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TargetBromodomain-containing protein 4 [342-460]/[42-168]
LigandBDBM111089
Substrate/Competitorn/a
Meas. Tech.Amplified Luminescent Proximity Homogeneous Assay (ALPHA)
Temperature298.15±n/a K
IC50 670000±n/a nM
Commentsextracted
Citation Vankayalapati, HYoshioka, MStrovel, JWPadia, JK Methods and compositions for inhibition of bromodomain-containing proteins US Patent US9695179 Publication Date 7/4/2017
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 [342-460]/[42-168]
Name:Bromodomain-containing protein 4 [342-460]/[42-168]
Synonyms:BRD4-BD1-BD2
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 3 components.
Component 1
Name:Bromodomain-containing protein 4 [42-168]
Synonyms:BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:Enzyme Catalytic Domain
Mol. Mass.:15054.68
Organism:Homo sapiens (Human)
Description:O60885[42-168]
Residue:127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
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Component 2
Name:Bromodomain-containing protein 4 [342-460]
Synonyms:BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:Enzyme Catalytic Domain
Mol. Mass.:13783.81
Organism:Homo sapiens (Human)
Description:a.a. 342-460 (BRD4-BD2)
Residue:119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMS
TIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
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BDBM111089
n/a
NameBDBM111089
Synonyms:US9695179, 86
TypeSmall organic molecule
Emp. Form.C27H20Cl2N2O6S
Mol. Mass.571.429
SMILESCOc1ccc(Cn2c3ccc(Cl)cc3c(OS(=O)(=O)c3ccc(Cl)cc3)c(-c3coc(C)n3)c2=O)cc1
Structure
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