| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 1 |
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| Ligand | BDBM201017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Human DPPI |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.200±n/a nM |
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| Comments | extracted |
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| Citation |  Vintonyak, V; Grauert, M; Grundl, M; Pautsch, A Substituted spirocycles US Patent US9879026 Publication Date 1/30/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 1 |
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| Name: | Dipeptidyl peptidase 1 |
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| Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51857.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53634 |
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| Residue: | 463 |
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| Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
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| BDBM201017 |
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| n/a |
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| Name | BDBM201017 |
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| Synonyms: | US9540373, 6 | US9879026, Example 6 | USRE47636, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32FN5O2 |
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| Mol. Mass. | 501.5951 |
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| SMILES | CN1CCC2(CC1)C(=O)Nc1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1 |r| |
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| Structure | 
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