Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase A |
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Ligand | BDBM85116 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PPIase Assay |
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Ki | 6.8e+3± 1.9e+3 nM |
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Citation | Dunsmore, CJ; Malone, KJ; Bailey, KR; Wear, MA; Florance, H; Shirran, S; Barran, PE; Page, AP; Walkinshaw, MD; Turner, NJ Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans. Chembiochem12:802-10 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase A |
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Name: | Peptidyl-prolyl cis-trans isomerase A |
Synonyms: | CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A |
Type: | Protein |
Mol. Mass.: | 18015.32 |
Organism: | Homo sapiens (Human) |
Description: | P62937 |
Residue: | 165 |
Sequence: | MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
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BDBM85116 |
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n/a |
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Name | BDBM85116 |
Synonyms: | Cyclophilin Inhibitor, 15 | Cyclophilin Inhibitor, 3b |
Type | Small organic molecule |
Emp. Form. | C18H27NO4 |
Mol. Mass. | 321.4113 |
SMILES | COC(=O)[C@H](CCCCN)C1C(=O)CC2C1=CC(=O)CC2(C)C |r,t:16| |
Structure |
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