| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin D |
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| Ligand | BDBM50055925 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In-Vitro Fluorescence Assay |
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| pH | 5.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 8.60±n/a nM |
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| Comments | extracted |
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| Citation |  Tsaklakidis, C; Klein, M; Czodrowski, P Acylguanidines for treating osteoarthritis US Patent US9884814 Publication Date 2/6/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cathepsin D |
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| Name: | Cathepsin D |
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| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 44551.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
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| Residue: | 412 |
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| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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|
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| BDBM50055925 |
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| n/a |
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| Name | BDBM50055925 |
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| Synonyms: | CHEMBL3321939 | US9884814, Compound 99 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36BrFN4O5 |
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| Mol. Mass. | 607.512 |
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| SMILES | COc1cc(CNC(=O)[C@@H](CC2CCCCC2)NC(=N)NC(=O)Cc2cc(OC)c(OC)cc2Br)ccc1F |r| |
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| Structure | 
|
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