Reaction Details |
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Target | Alpha-1A adrenergic receptor |
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Ligand | BDBM85228 |
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Substrate/Competitor | n/a |
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Ki | >10000±n/a nM |
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Comments | PDSP_6972 |
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Citation | Schaus, JM; Thompson, DC; Bloomquist, WE; Susemichel, AD; Calligaro, DO; Cohen, ML Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: indazole and benzimidazolone derivatives. J Med Chem41:1943-55 (1998) [PubMed] Article |
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More Info.: | Get all data from this article |
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Alpha-1A adrenergic receptor |
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Name: | Alpha-1A adrenergic receptor |
Synonyms: | ADA1A_RAT | Adra1a | Adra1c | Alpha-1 adrenoreceptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | adrenergic Alpha1A |
Type: | Protein |
Mol. Mass.: | 51620.15 |
Organism: | Rattus norvegicus (Rat) |
Description: | P43140 |
Residue: | 466 |
Sequence: | MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
VPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTL
HPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACT
TARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
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BDBM85228 |
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n/a |
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Name | BDBM85228 |
Synonyms: | N-(1-(2-((N-Methylsulfonyl)amino)ethyl)piperidin-4-yl)-1-isopropylindazole-3-carboxamide Maleate |
Type | Small organic molecule |
Emp. Form. | C19H29N5O3S |
Mol. Mass. | 407.53 |
SMILES | CC(C)n1nc(C(=O)NC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12 |
Structure |
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