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TargetUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
LigandBDBM85277
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
pH8±0
Temperature310.15±0 K
IC50 1.50e+5±n/a nM
Citation Sova, MKovac, ATurk, SHrast, MBlanot, DGobec, S Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF. Bioorg Chem37:217-22 (2009) [PubMed]  Article
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UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Name:UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Synonyms:MURF_ECOLI | MurF (E. coli) | mra | murF
Type:Protein
Mol. Mass.:47439.03
Organism:Escherichia coli
Description:P11880
Residue:452
Sequence:
MISVTLSQLTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAG
GAGALLVSRPLDIDLPQLIVKDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAA
ILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELGANHQGEIAWTVSLTRPEAAL
VNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRFS
PNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATL
DAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANVGSMTAAVQVLAEMPGYRVLVVGD
MAELGAESEACHVQVGEAAKAAGIDRVLSVGKQSHAISTASGVGEHFADKTALITRLKLL
IAEQQVITILVKGSRSAAMEEVVRALQENGTC
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BDBM85277
n/a
NameBDBM85277
Synonyms:HEA derivative, 7d
TypeSmall organic molecule
Emp. Form.C14H20F3N2O7PS
Mol. Mass.448.352
SMILESOP(O)(=O)OC(CNS(=O)(=O)c1cccc(c1)C(F)(F)F)CN1CCOCC1
Structure
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