| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
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| Ligand | BDBM85278 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| pH | 8±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 5.60e+5±n/a nM |
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| Citation |  Sova, M; Kovac, A; Turk, S; Hrast, M; Blanot, D; Gobec, S Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF. Bioorg Chem37:217-22 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
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| Name: | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
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| Synonyms: | MURF_ECOLI | MurF (E. coli) | mra | murF |
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| Type: | Protein |
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| Mol. Mass.: | 47439.03 |
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| Organism: | Escherichia coli |
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| Description: | P11880 |
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| Residue: | 452 |
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| Sequence: | MISVTLSQLTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAG
GAGALLVSRPLDIDLPQLIVKDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAA
ILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELGANHQGEIAWTVSLTRPEAAL
VNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRFS
PNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATL
DAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANVGSMTAAVQVLAEMPGYRVLVVGD
MAELGAESEACHVQVGEAAKAAGIDRVLSVGKQSHAISTASGVGEHFADKTALITRLKLL
IAEQQVITILVKGSRSAAMEEVVRALQENGTC
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| BDBM85278 |
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| n/a |
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| Name | BDBM85278 |
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| Synonyms: | HEA derivative, 7e |
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| Type | Small organic molecule |
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| Emp. Form. | C14H23N2O7PS |
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| Mol. Mass. | 394.38 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)NCC(CN1CCOCC1)OP(O)(O)=O |
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| Structure | 
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