| Reaction Details |
|---|
 | Report a problem with these data |
| Target | HIV-1 protease |
|---|
| Ligand | BDBM50001103 |
|---|
| Substrate/Competitor | n/a |
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| Meas. Tech. | HIV-1 plaque reduction assay |
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| EC50 | 16000±n/a nM |
|---|
| Citation |  Hostetler, KY; Beadle, JR Phosphonate compounds US Patent US10071110 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| HIV-1 protease |
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| Name: | HIV-1 protease |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 10794.16 |
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| Organism: | Human immunodeficiency virus |
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| Description: | Q9YQ34 |
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| Residue: | 99 |
|---|
| Sequence: | PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
|---|
| BDBM50001103 |
|---|
| n/a |
|---|
| Name | BDBM50001103 |
|---|
| Synonyms: | (2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic acid | (PMEA)[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid | 9-(2-(phosphonomethoxy)ethyl)adenine | 9-[(2-phosphonylmethoxy)ethyl]adenine | 9-[2-(phosphonomethoxy)ethyl]adenine | 9-[2-phosphonomethoxyethyl]adenine | 9-[3-(Phosphonomethoxy)ethyl]adenine (PMEA) | ADEFOVIR | CHEMBL484 | GS-0393 | US10071110, Compound Adefovir | [2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid | [2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid(PMEA) | [2-(6-amino-9H-purin-9-yl)ethoxy]methylphosphonic acid | {[2-(6-AMINO-9H-PURIN-9-YL)ETHOXY]METHYL}PHOSPHONIC ACID |
|---|
| Type | Small organic molecule |
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| Emp. Form. | C8H12N5O4P |
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| Mol. Mass. | 273.1857 |
|---|
| SMILES | Nc1ncnc2n(CCOCP(O)(O)=O)cnc12 |
|---|
| Structure | 
|
|---|
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