Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50143784 |
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Substrate/Competitor | n/a |
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Ki | 0.03±n/a nM |
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Comments | PDSP_999 |
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Citation | Nishikibe, M; Ohta, H; Okada, M; Ishikawa, K; Hayama, T; Fukuroda, T; Noguchi, K; Saito, M; Kanoh, T; Ozaki, S; Kamei, T; Hara, K; William, D; Kivlighn, S; Krause, S; Gabel, R; Zingaro, G; Nolan, N; O'Brien, J; Clayton, F; Lynch, J; Pettibone, D; Siegl, P Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist. J Pharmacol Exp Ther289:1262-70 (1999) [PubMed] |
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More Info.: | Get all data from this article |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48736.88 |
Organism: | Homo sapiens (Human) |
Description: | P25101 |
Residue: | 427 |
Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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BDBM50143784 |
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n/a |
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Name | BDBM50143784 |
Synonyms: | (5S,6R,7R)-5-Benzo[1,3]dioxol-5-yl-2-butyl-7-[2-((S)-2-carboxy-propyl)-4-methoxy-phenyl]-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid | CHEMBL305576 | J-104132 |
Type | Small organic molecule |
Emp. Form. | C31H33NO7 |
Mol. Mass. | 531.5962 |
SMILES | CCCCc1ccc2[C@@H]([C@H]([C@@H](c2n1)c1ccc(OC)cc1C[C@H](C)C(O)=O)C(O)=O)c1ccc2OCOc2c1 |
Structure |
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