Reaction Details |
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Target | S-adenosylmethionine synthase isoform type-2 |
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Ligand | BDBM85451 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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pH | 7.5±0 |
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Temperature | 310.15±0 K |
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Ki | 140000±0.0 nM |
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IC50 | 300000±0.0 nM |
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Citation | Lavrador, K; Allart, B; Guillerm, D; Guillerm, G A new series of S-adenosyl-L-methionine synthetase inhibitors. J Enzym Inhib13:361-7 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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S-adenosylmethionine synthase isoform type-2 |
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Name: | S-adenosylmethionine synthase isoform type-2 |
Synonyms: | AdoMet synthetase 2 | Ams2 | MAT 2 | MAT-II | METK2_RAT | Mat2a | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-Adenosylmethionine Synthase (AdoMet) | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2 |
Type: | PROTEIN |
Mol. Mass.: | 43713.68 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_105118 |
Residue: | 395 |
Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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BDBM85451 |
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n/a |
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Name | BDBM85451 |
Synonyms: | Epithioamino acid analogue, II(b) |
Type | Small organic molecule |
Emp. Form. | C6H11NO2S |
Mol. Mass. | 161.222 |
SMILES | C[C@H]1S[C@@H]1C[C@H](N)C(O)=O |r| |
Structure |
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