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TargetNeutrophil elastase
LigandBDBM85461
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
Temperature298.15±n/a K
Ki 2.07e+5±n/a nM
Commentsextracted
Citation Vicentini, CBGuarneri, MAndrisano, VGuccione, SLanger, TMarschhofer, RChabin, REdison, AMHuang, XKnight, WBGiori, P Potential of pyrazolooxadiazinone derivatives as serine protease inhibitors. J Enzym Inhib16:15-34 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM85461
n/a
NameBDBM85461
Synonyms:Pyrazolooxadiazinone, 2b
TypeSmall organic molecule
Emp. Form.C6H8N4O2
Mol. Mass.168.1533
SMILESCc1nn(C)c2NC(=O)ONc12
Structure
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