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TargetCyclooxygenase-1 (COX-1)
LigandBDBM50090676
Substrate/Competitorn/a
Ki 1100±n/a nM
CommentsPDSP_4463
Citation Warner TDGiuliano FVojnovic IBukasa AMitchell JAVane JR Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A 96:7563-8 (1999) [PubMed]
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Cyclooxygenase-1 (COX-1)
Name:Cyclooxygenase
Synonyms:COX-1 | Cyclooxygenase-1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:Enzyme
Mol. Mass.:68692.62
Organism:Homo sapiens (Human)
Description:P23219
Residue:599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
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  Blast E-value cutoff:
BDBM50090676
n/a
NameBDBM50090676
Synonyms:(+-)-2-(p-(2-thenoyl)phenyl)propionic acid | 2-(4-(2-Thenoyl)phenyl)propionsaeure | 2-[4-(thiophen-2-ylcarbonyl)phenyl]propanoic acid | 4-(2-Thenoyl)hydratropsaeure | CHEMBL956 | SUPROFEN | alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid | p-2-thenoylhydratropic acid
TypeSmall organic molecule
Emp. Form.C14H12O3S
Mol. Mass.260.308
SMILESCC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
Structure
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