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TargetProstaglandin E2 receptor EP3 subtype
LigandBDBM22369
Substrate/Competitorn/a
Ki 41±n/a nM
CommentsPDSP_4000
Citation Chan, CCBoyce, SBrideau, CCharleson, SCromlish, WEthier, DEvans, JFord-Hutchinson, AWForrest, MJGauthier, JYGordon, RGresser, MGuay, JKargman, SKennedy, BLeblanc, YLeger, SMancini, JO'Neill, GPOuellet, MPatrick, DPercival, MDPerrier, HPrasit, PRodger, I Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther290:551-60 (1999) [PubMed]
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Prostaglandin E2 receptor EP3 subtype
Name:Prostaglandin E2 receptor EP3 subtype
Synonyms:PE2R3_RAT | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor EP3 subtype | Prostanoid EP3 receptor | Ptger3
Type:Enzyme Catalytic Domain
Mol. Mass.:39958.37
Organism:RAT
Description:Prostaglandin E2 PTGER2 RAT::P34980
Residue:365
Sequence:
MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESK
RKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLS
SLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWP
GTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKA
AASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKE
CNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWS
DQLER
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  Blast E-value cutoff:
BDBM22369
n/a
NameBDBM22369
Synonyms:4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one | CHEMBL122 | MK 0966 | Rofecoxib | US11478464, Compound Rofecoxib | US11786535, Compound Rofecoxib
TypeSmall organic molecule
Emp. Form.C17H14O4S
Mol. Mass.314.356
SMILESCS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1 |t:11|
Structure
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