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TargetPTGER2
LigandBDBM22369
Substrate/Competitorn/a
Ki 41±n/a nM
CommentsPDSP_4000
Citation Chan CCBoyce SBrideau CCharleson SCromlish WEthier DEvans JFord-Hutchinson AWForrest MJGauthier JYGordon RGresser MGuay JKargman SKennedy BLeblanc YLeger SMancini JO'Neill GPOuellet MPatrick DPercival MDPerrier HPrasit PRodger I Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther 290:551-60 (1999) [PubMed]
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PTGER2
Name:PTGER2
Synonyms:Prostaglandin E2 | Prostaglandin E2 receptor EP3 subtype | Prostanoid EP3 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:39958.37
Organism:RAT
Description:Prostaglandin E2 PTGER2 RAT::P34980
Residue:365
Sequence:
MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESK
RKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLS
SLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWP
GTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKA
AASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKE
CNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWS
DQLER
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  Blast E-value cutoff:
BDBM22369
n/a
NameBDBM22369
Synonyms:4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofuran-2-one | CHEMBL122 | MK 0966 | Rofecoxib
TypeSmall organic molecule
Emp. Form.C17H14O4S
Mol. Mass.314.356
SMILESCS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1 |t:11|
Structure
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