Reaction Details |
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Target | 5-hydroxytryptamine receptor 3A |
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Ligand | BDBM50249134 |
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Substrate/Competitor | n/a |
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Ki | 1000±n/a nM |
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Comments | PDSP_3873 |
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Citation | Bonhaus, DW; Flippin, LA; Greenhouse, RJ; Jaime, S; Rocha, C; Dawson, M; Van Natta, K; Chang, LK; Pulido-Rios, T; Webber, A; Leung, E; Eglen, RM; Martin, GR RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol127:1075-82 (1999) [PubMed] Article |
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More Info.: | Get all data from this article |
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5-hydroxytryptamine receptor 3A |
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Name: | 5-hydroxytryptamine receptor 3A |
Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 |
Type: | Protein |
Mol. Mass.: | 55283.27 |
Organism: | Homo sapiens (Human) |
Description: | P46098 |
Residue: | 478 |
Sequence: | MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ
STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ
ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
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BDBM50249134 |
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n/a |
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Name | BDBM50249134 |
Synonyms: | 4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine | CHEMBL473186 | RS-127445 |
Type | Small organic molecule |
Emp. Form. | C17H16FN3 |
Mol. Mass. | 281.3274 |
SMILES | CC(C)c1cc(nc(N)n1)-c1ccc(F)c2ccccc12 |
Structure |
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