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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lysine-specific demethylase 2A | ||
| Ligand | BDBM276042 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | FBXL11 Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <100±n/a nM | ||
| Comments | extracted | ||
| Citation |  Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lysine-specific demethylase 2A | |||
| Name: | Lysine-specific demethylase 2A | ||
| Synonyms: | AA1-1162 | CXXC8 | F-box and leucine-rich repeat protein 11 | FBL11 | FBL7 | FBXL11 | Homo sapiens lysine demethylase 2A (KDM2A) | JHDM1A | KDM2A | KDM2A_HUMAN | KIAA1004 | Lysine-specific demethylase 2A | Lysine-specific demethylase 2A (KDM2A) | NM_012308 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 132809.04 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 1162 | ||
| Sequence: |
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| BDBM276042 | |||
| n/a | |||
| Name | BDBM276042 | ||
| Synonyms: | 2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-4-(1H-triazol-4-yl)pyridine | US10071984, Example 4 | US10174003, Example 4 | US9896436, Example 4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H19FN6O | ||
| Mol. Mass. | 390.4136 | ||
| SMILES | Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1c[nH]nn1 |(1.71,-3.53,;.22,-3.92,;-.68,-5.17,;-2.15,-4.69,;-2.15,-3.15,;-.68,-2.68,;-.29,-1.19,;-1.37,-.1,;-.98,1.39,;.51,1.78,;.91,3.27,;1.6,.7,;1.2,-.79,;2.29,-1.88,;3.78,-1.48,;4.87,-2.57,;5.27,-4.06,;6.36,-2.97,;-3.48,-2.38,;-3.48,-.84,;-4.82,-.07,;-6.15,-.84,;-6.15,-2.38,;-4.82,-3.15,;-4.82,1.47,;-6.06,2.37,;-5.59,3.84,;-4.05,3.84,;-3.57,2.37,)| | ||
| Structure | 
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