Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Isoform 2 of Histone lysine demethylase PHF8 (2) | ||
Ligand | BDBM276042 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | PHF8 Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 5500±n/a nM | ||
Comments | extracted | ||
Citation | Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Isoform 2 of Histone lysine demethylase PHF8 (2) | |||
Name: | Isoform 2 of Histone lysine demethylase PHF8 (2) | ||
Synonyms: | Histone lysine demethylase PHF8 (2) | KIAA1111 | NP_055922 | PHF8 | PHF8_HUMAN | ZNF422 | histone lysine demethylase PHF8 isoform 2 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 113932.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9UPP1-2 | ||
Residue: | 1024 | ||
Sequence: |
| ||
BDBM276042 | |||
n/a | |||
Name | BDBM276042 | ||
Synonyms: | 2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]-4-(1H-triazol-4-yl)pyridine | US10071984, Example 4 | US10174003, Example 4 | US9896436, Example 4 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H19FN6O | ||
Mol. Mass. | 390.4136 | ||
SMILES | Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1c[nH]nn1 |(1.71,-3.53,;.22,-3.92,;-.68,-5.17,;-2.15,-4.69,;-2.15,-3.15,;-.68,-2.68,;-.29,-1.19,;-1.37,-.1,;-.98,1.39,;.51,1.78,;.91,3.27,;1.6,.7,;1.2,-.79,;2.29,-1.88,;3.78,-1.48,;4.87,-2.57,;5.27,-4.06,;6.36,-2.97,;-3.48,-2.38,;-3.48,-.84,;-4.82,-.07,;-6.15,-.84,;-6.15,-2.38,;-4.82,-3.15,;-4.82,1.47,;-6.06,2.37,;-5.59,3.84,;-4.05,3.84,;-3.57,2.37,)| | ||
Structure |