| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Isoform 2 of Histone lysine demethylase PHF8 (2) |
|---|
| Ligand | BDBM276063 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PHF8 Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 5500±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Isoform 2 of Histone lysine demethylase PHF8 (2) |
|---|
| Name: | Isoform 2 of Histone lysine demethylase PHF8 (2) |
|---|
| Synonyms: | Histone lysine demethylase PHF8 (2) | KIAA1111 | NP_055922 | PHF8 | PHF8_HUMAN | ZNF422 | histone lysine demethylase PHF8 isoform 2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 113932.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UPP1-2 |
|---|
| Residue: | 1024 |
|---|
| Sequence: | MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPS
IMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENS
FSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYY
SGKREKVLNVISLEFSDTRLSNLVETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVR
DSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKC
YKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFR
FPNFETICWYVGKHILDIFRGLRENRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEI
PETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMS
RLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQK
AKFNITGACLNDSDDDSPDLDLDGNESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKAR
LMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEV
EFDIEEDYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQE
AIQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPI
KRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDD
APWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLL
KEVEQPRPQDSNLSLTVPAPTVAATPQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNA
FGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNG
KLLL
|
|
|
|---|
| BDBM276063 |
|---|
| n/a |
|---|
| Name | BDBM276063 |
|---|
| Synonyms: | 2-[5-(3-ethoxy-4-fluorophenyl)-1-methylimidazol-4-yl]-4-(1H-triazol-4-yl)pyridine | US10071984, Example 25 | US10174003, Example 25 | US9896436, Example 25 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17FN6O |
|---|
| Mol. Mass. | 364.3763 |
|---|
| SMILES | CCOc1cc(ccc1F)-c1c(ncn1C)-c1cc(ccn1)-c1c[nH]nn1 |
|---|
| Structure | 
|
|---|
Search and Browse
