| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 2 of Histone lysine demethylase PHF8 (2) |
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| Ligand | BDBM276066 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PHF8 Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 550±n/a nM |
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| Comments | extracted |
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| Citation |  Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 2 of Histone lysine demethylase PHF8 (2) |
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| Name: | Isoform 2 of Histone lysine demethylase PHF8 (2) |
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| Synonyms: | Histone lysine demethylase PHF8 (2) | KIAA1111 | NP_055922 | PHF8 | PHF8_HUMAN | ZNF422 | histone lysine demethylase PHF8 isoform 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 113932.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UPP1-2 |
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| Residue: | 1024 |
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| Sequence: | MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPS
IMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENS
FSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYY
SGKREKVLNVISLEFSDTRLSNLVETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVR
DSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKC
YKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFR
FPNFETICWYVGKHILDIFRGLRENRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEI
PETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMS
RLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQK
AKFNITGACLNDSDDDSPDLDLDGNESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKAR
LMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEV
EFDIEEDYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQE
AIQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPI
KRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDD
APWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLL
KEVEQPRPQDSNLSLTVPAPTVAATPQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNA
FGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNG
KLLL
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| BDBM276066 |
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| n/a |
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| Name | BDBM276066 |
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| Synonyms: | 2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-yl]-4-(1H-triazol-4-yl)pyridin | US10071984, Example 28 | US10174003, Example 28 | US9896436, Example 28 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15FN6 |
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| Mol. Mass. | 334.3503 |
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| SMILES | Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F |
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| Structure | 
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