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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lysine-specific demethylase 2B | ||
| Ligand | BDBM276078 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | FBXL10 Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <100±n/a nM | ||
| Comments | extracted | ||
| Citation |  Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lysine-specific demethylase 2B | |||
| Name: | Lysine-specific demethylase 2B | ||
| Synonyms: | AA 1-650 | CXXC2 | FBL10 | FBXL10 | Homo sapiens lysine demethylase 2B (KDM2B) | JHDM1B | KDM2B | KDM2B_HUMAN | Lysine-specific demethylase 2B | Lysine-specific demethylase 2B (KDM2B) | NDY1 | NM_032590 | PCCX2 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 152658.35 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q8NHM5 | ||
| Residue: | 1336 | ||
| Sequence: |
| ||
| BDBM276078 | |||
| n/a | |||
| Name | BDBM276078 | ||
| Synonyms: | 4-(5-chloro-1H-triazol-4-yl)-2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methylimidazol-4-yl]pyridine | US10071984, Example 40 | US10174003, Example 40 | US9896436, Example 40 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H18ClFN6O | ||
| Mol. Mass. | 424.859 | ||
| SMILES | Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1Cl |(2.23,-3.53,;.74,-3.92,;-.16,-5.17,;-1.63,-4.69,;-1.63,-3.15,;-.16,-2.68,;.23,-1.19,;-.85,-.1,;-.46,1.39,;1.03,1.78,;1.43,3.27,;2.12,.7,;1.72,-.79,;2.81,-1.88,;4.3,-1.48,;5.39,-2.57,;5.79,-4.06,;6.88,-2.97,;-2.96,-2.38,;-2.96,-.84,;-4.3,-.07,;-5.63,-.84,;-5.63,-2.38,;-4.3,-3.15,;-4.3,1.47,;-3.05,2.37,;-3.53,3.84,;-5.07,3.84,;-5.54,2.37,;-6.88,1.6,)| | ||
| Structure | 
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