| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 2 of Histone lysine demethylase PHF8 (2) |
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| Ligand | BDBM276086 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PHF8 Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 5500±n/a nM |
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| Comments | extracted |
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| Citation |  Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 2 of Histone lysine demethylase PHF8 (2) |
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| Name: | Isoform 2 of Histone lysine demethylase PHF8 (2) |
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| Synonyms: | Histone lysine demethylase PHF8 (2) | KIAA1111 | NP_055922 | PHF8 | PHF8_HUMAN | ZNF422 | histone lysine demethylase PHF8 isoform 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 113932.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UPP1-2 |
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| Residue: | 1024 |
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| Sequence: | MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPS
IMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENS
FSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYY
SGKREKVLNVISLEFSDTRLSNLVETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVR
DSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKC
YKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFR
FPNFETICWYVGKHILDIFRGLRENRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEI
PETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMS
RLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQK
AKFNITGACLNDSDDDSPDLDLDGNESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKAR
LMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEV
EFDIEEDYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQE
AIQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPI
KRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDD
APWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLL
KEVEQPRPQDSNLSLTVPAPTVAATPQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNA
FGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNG
KLLL
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| BDBM276086 |
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| n/a |
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| Name | BDBM276086 |
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| Synonyms: | 1-[(3,4-dichlorophenyl)methyl]-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazole | US10071984, Example 48 | US10174003, Example 48 | US9896436, Example 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10Cl2N6 |
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| Mol. Mass. | 345.186 |
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| SMILES | Clc1ccc(Cn2cnc(c2)-c2cc3[nH]nnc3cn2)cc1Cl |
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| Structure | 
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