Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetIsoform 2 of Histone lysine demethylase PHF8 (2)
LigandBDBM276090
Substrate/Competitorn/a
Meas. Tech.PHF8 Assay
Temperature298.15±n/a K
IC50 5500±n/a nM
Commentsextracted
Citation Chen, YKNie, ZStafford, JAVeal, JM Histone demethylase inhibitors US Patent US10071984 Publication Date 9/11/2018
More Info.:Get all data from this article,  Assay Method
 
Isoform 2 of Histone lysine demethylase PHF8 (2)
Name:Isoform 2 of Histone lysine demethylase PHF8 (2)
Synonyms:Histone lysine demethylase PHF8 (2) | KIAA1111 | NP_055922 | PHF8 | PHF8_HUMAN | ZNF422 | histone lysine demethylase PHF8 isoform 2
Type:Enzyme Catalytic Domain
Mol. Mass.:113932.27
Organism:Homo sapiens (Human)
Description:Q9UPP1-2
Residue:1024
Sequence:
MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPS
IMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENS
FSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYY
SGKREKVLNVISLEFSDTRLSNLVETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVR
DSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKC
YKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFR
FPNFETICWYVGKHILDIFRGLRENRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEI
PETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMS
RLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQK
AKFNITGACLNDSDDDSPDLDLDGNESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKAR
LMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEV
EFDIEEDYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQE
AIQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPI
KRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDD
APWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLL
KEVEQPRPQDSNLSLTVPAPTVAATPQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNA
FGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNG
KLLL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM276090
n/a
NameBDBM276090
Synonyms:1-(3,5-dichlorophenyl)-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazole | US10071984, Example 52 | US10174003, Example 52 | US9896436, Example 52
TypeSmall organic molecule
Emp. Form.C14H8Cl2N6
Mol. Mass.331.16
SMILESClc1cc(Cl)cc(c1)-n1cnc(c1)-c1cc2[nH]nnc2cn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: