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Targethistone lysine demethylase PHF8 isoform 2
LigandBDBM276092
Substrate/Competitorn/a
Meas. Tech.PHF8 Assay
Temperature298.15±n/a K
IC50 5500±n/a nM
Commentsextracted
Citation Chen YKNie ZStafford JAVeal JM Histone demethylase inhibitors US Patent  US10071984 Publication Date 9/11/2018
More Info.:Get all data from this article,  Assay Method
 
histone lysine demethylase PHF8 isoform 2
Name:histone lysine demethylase PHF8 isoform 2
Synonyms:NP_055922 | PHF8
Type:Enzyme Catalytic Domain
Mol. Mass.:113932.27
Organism:Homo sapiens (Human)
Description:n/a
Residue:1024
Sequence:
MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPS
IMKKRRGSSKGHDTHKGKPVKTGSPTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENS
FSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYY
SGKREKVLNVISLEFSDTRLSNLVETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVR
DSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKC
YKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFR
FPNFETICWYVGKHILDIFRGLRENRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEI
PETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMS
RLSLPSKNGSKKKGLKPKELFKKAERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQK
AKFNITGACLNDSDDDSPDLDLDGNESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKAR
LMAEQVMEDEFDLDSDDELQIDERLGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEV
EFDIEEDYTTDEDMVEGVEGKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQE
AIQGMLCMANLQSSSSSPATSSLQAWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPI
KRPAYWRTESEEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDD
APWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLL
KEVEQPRPQDSNLSLTVPAPTVAATPQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNA
FGMAQANRSTTPMAPGVFLTQRRPSVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNG
KLLL
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  Blast E-value cutoff:
BDBM276092
n/a
NameBDBM276092
Synonyms:5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazole | US10071984, Example 54 | US10174003, Example 54
TypeSmall organic molecule
Emp. Form.C19H17FN6O
Mol. Mass.364.3763
SMILESCn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1 |(2.41,-2.3,;.92,-2.7,;.45,-4.16,;-1.09,-4.16,;-1.57,-2.7,;-.32,-1.79,;.07,-.3,;-1.01,.79,;-.62,2.27,;.87,2.67,;1.27,4.16,;1.96,1.58,;1.56,.1,;2.65,-.99,;4.14,-.59,;5.23,-1.68,;5.63,-3.17,;6.72,-2.08,;-2.9,-1.93,;-2.9,-.39,;-4.24,.38,;-4.56,1.89,;-6.09,2.05,;-6.72,.65,;-5.57,-.39,;-5.57,-1.93,;-4.24,-2.7,)|
Structure
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