| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
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| Ligand | BDBM276134 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | NR2B standard assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | <1±n/a nM |
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| Comments | Zero 12/22/2021 |
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| Citation |  Chen, G; Chrovian, CC; Coate, HR; Dvorak, CA; Gelin, CF; Hiscox, A; Letavic, MA; Rech, JC; Soyode-Johnson, A; Stenne, B; Wall, JL; Zhang, W Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators US Patent US10071988 Publication Date 9/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-alpha |
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| Name: | Retinoic acid receptor RXR-alpha |
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| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50820.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456363 |
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| Residue: | 462 |
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| Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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| BDBM276134 |
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| n/a |
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| Name | BDBM276134 |
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| Synonyms: | 2-[[1-(3-Bromo-4-fluoro-phenyl)triazol-4-yl]methoxy]-5-methoxy- | US10071988, Example 41 | US10233173, Example 41 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11BrFN5O2 |
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| Mol. Mass. | 380.172 |
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| SMILES | COc1cnc(OCc2cn(nn2)-c2ccc(F)c(Br)c2)nc1 |
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| Structure | 
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