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TargetRetinoic acid receptor RXR-alpha
LigandBDBM276569
Substrate/Competitorn/a
Meas. Tech.NR2B standard assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 3.00±n/a nM
Commentsextracted
Citation Chen, GChrovian, CCCoate, HRDvorak, CAGelin, CFHiscox, ALetavic, MARech, JCSoyode-Johnson, AStenne, BWall, JLZhang, W Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators US Patent US10071988 Publication Date 9/11/2018
More Info.:Get all data from this article,  Assay Method
 
Retinoic acid receptor RXR-alpha
Name:Retinoic acid receptor RXR-alpha
Synonyms:NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:PROTEIN
Mol. Mass.:50820.38
Organism:Homo sapiens (Human)
Description:ChEMBL_1456363
Residue:462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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  Blast E-value cutoff:
BDBM276569
n/a
NameBDBM276569
Synonyms:4-(Azetidin-1-yl)-2-[[1-[3-(difluoromethoxy)-4-fluoro-phenyl]triazol-4- | US10071988, Example 509 | US10233173, Example 509
TypeSmall organic molecule
Emp. Form.C17H15F3N6O2
Mol. Mass.392.3352
SMILESFC(F)Oc1cc(ccc1F)-n1cc(COc2nccc(n2)N2CCC2)nn1
Structure
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