| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Ligand | BDBM85683 |
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| Substrate/Competitor | n/a |
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| Ki | 200±n/a nM |
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| Comments | PDSP_555 |
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| Citation |  Vanover, KE; Rosenzweig-Lipson, S; Hawkinson, JE; Lan, NC; Belluzzi, JD; Stein, L; Barrett, JE; Wood, PL; Carter, RB Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors. J Pharmacol Exp Ther295:337-45 (2000) [PubMed] |
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| More Info.: | Get all data from this article |
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| Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Synonyms: | GABA A Alpha2Beta2Gamma2 | GABA A alpha2 | GABA A receptor alpha-2/beta-2/gamma-2 | GABA receptor alpha-2 subunit | GABA(A) receptor subunit alpha-2 | GBRA2_RAT | Gabra-2 | Gabra2 | Gamma-aminobutyric acid receptor subunit alpha-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 51195.57 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P23576 |
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| Residue: | 451 |
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| Sequence: | MRTKLSTCNVWFPLLVLLVWNPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPG
LGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNSMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSC
PLKFGSYAYTTSEVTYIWTYNPSDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVM
TAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGSV
MIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRM
SRIVFPVLFGTFNLVYWATYLNREPVLGVSP
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| BDBM85683 |
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| n/a |
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| Name | BDBM85683 |
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| Synonyms: | Co 2-6749 | Co-2-6749 | GMA-839 | WAY-141839 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H31F3O3 |
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| Mol. Mass. | 388.4642 |
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| SMILES | C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](O)(CC[C@H]34)C(F)(F)F)[C@@H]1CC[C@@H]2C(=O)CO |
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| Structure | 
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