| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Ligand | BDBM50045050 |
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| Substrate/Competitor | n/a |
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| Ki | 1900±n/a nM |
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| Comments | PDSP_264 |
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| Citation |  Vanover, KE; Rosenzweig-Lipson, S; Hawkinson, JE; Lan, NC; Belluzzi, JD; Stein, L; Barrett, JE; Wood, PL; Carter, RB Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors. J Pharmacol Exp Ther295:337-45 (2000) [PubMed] |
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| More Info.: | Get all data from this article |
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| Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Name: | Gamma-aminobutyric acid receptor subunit alpha-4 |
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| Synonyms: | GBRA4_RAT | Gabra4 | Gamma-aminobutyric acid receptor (GABA(A)) subunit alpha-4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 60972.37 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P28471 |
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| Residue: | 552 |
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| Sequence: | MVSVQKVPAIVLCSGVSLALLHVLCLATCLNESPGQNSKDEKLCPENFTRILDSLLDGYD
NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN
NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP
MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT
GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT
TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPP
EVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVNSRTEVGNHSSKTTAAQESS
ETTPKAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASARPAFGAR
LGRIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYL
SKDTMEKSESLM
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| BDBM50045050 |
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| n/a |
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| Name | BDBM50045050 |
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| Synonyms: | 1-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-ethanone | Allopregnanolone | CHEMBL435035 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H34O2 |
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| Mol. Mass. | 318.4935 |
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| SMILES | CC(=O)C1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C |
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| Structure | 
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